YB90079Si01

Interleukin 6 (IL6)

Organism: Rhesus monkey (Simian)

Instruction manual

FOR IN VITRO USE AND RESEARCH USE ONLY

NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES

1th Edition (Revised in February, 2012)

[ DESCRIPTION ]

Protein Names: Interleukin 6

Gene Names: IL6

Size: 100µg

Source: Recombinant

Expression Host: E.coli

Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance

Subcellular Location: Secreted

[ PROPERTIES ]

Residues: Pro27~Met212 (Accession # P51494), with a N-terminal His-tag.

Grade & Purity: >97%, 24.91 kDa as determined by SDS-PAGE reducing

conditions.

Form & Buffer: Supplied as lyophilized form in PBS, pH 7.4.

Endotoxin Level: <1.0 EU per 1μg(determined by the LAL method).

Applications: SDS-PAGE; WB; ELISA; IP.

(May be suitable for use in other assays to be determined by the end user.)

Predicted Molecular Mass: 24.91 kDa

[ PREPARATION ]

Reconstitute in PBS.

[ STORAGE AND STABILITY ]

Storage: Store at 4oC for short term storage (1-2 weeks). Aliquot and store at -20oC or -80oC for long term storage. Avoid repeated freeze/thaw cycles.

Valid period: 12 months stored at -80oC.

[ BACKGROUND]

The target protein is fused with a His-tag and its sequence is listed below.

MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSEF-PAPV LPGEDSKNVA APHSQPLTSS ERIDKHIRYI

LDGISALRKE  TCNRSNMCES  SKEALAENNL NLPKMAEKDG  CFQSGFNEDT  CLVKIITGLL EFEVYLEYLQ

NRFESSEEQA RAVQMSTKVL  IQFLQKKAKN  LDAITTPEPT  TNASLLTKLQ AQNQWLQDMT  THLILRSFKE

FLQSNLRALR QM

[ REFERENCES ]

1. Villinger F.J., et.al. (1995) J. Immunol. 155:3946-3954.

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