System Biosciences (SBI) develops innovative research tools for Vector delivery technologies, MicroRNA research, Exosome research, and Genome Engineering tools, including the CRISPR-Cas9 SmartNuclease™ system and PrecisionX™ HR targeting vectors. Highlights: Vector Technologies: • Powerful lentivector systems • One-step transfection piggyBac transposons • Single-copy gene additions with phiC31 integrase vectors • Sustained expression without integration with Minicircle DNA plasmids Exosome Research Tools: • Isolate exosomes with ExoQuick and ExoQuick-TC • Exo-Flow- Immunopurify exosomes on magentic beads and anlayze by FACS • Culture cells in exosome-depleted FBS • Verify exosome recovery with antibodies • Quantitate exosomes with ELISAs Genome Engineering: • RNA-guided Cas9 SmartNuclease system • Fast and efficient mutation correction / gene editing • HR donor vectors for knock-in, knock-out & tagging • High-throughput, targeted integration with PinPoint technology Stem Cell Research: • iPSC reprogramming systems • Growth factors and media • Pluripotency confirmation kits and antibodies • iPS celllines, normal and disease models • Promoter lineage reporters in lentivectors Non-coding RNA: • LncRNA qPCR profiling kits • miRNome and OncoMir qPCR profiling systems • Lenti-miR Precursor clone libraries – arrayed and pooled • miRZip anti-miR clones for stable miRNA inhibition Exo-NGS Custom Service: • Provide serum, tissue culture media, or other patient biofluids to SBI • SBI isolates exosomes, purifies RNA and generates high quality NGS libraries • Sequencing performed using Illumina MiSeq and HiSeq platforms • Comprehensive data analysis, including generation of heat maps and top hits, provided • NGS data loaded onto a custom UCSC Genome Browser for convenient viewing

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